deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 3-arm NCT03303339

Onvansertib in Combination With Either Low-dose Cytarabine or Decitabine in Adult Patients With Acute Myeloid Leukemia (AML)

A Phase 1b/2 Study of PCM-075 (Onvansertib) in Combination With Either Low-Dose Cytarabine or Decitabine in Subjects With Acute Myeloid Leukemia (AML)

Sponsor: Cardiff Oncology

Conditions Acute Myeloid Leukemia
Interventions Cytarabine Decitabine Onvansertib
Updated 25 times since 2017 Last updated: Jan 31, 2023 Started: Nov 17, 2017 Primary completion: Nov 17, 2021 Completion: Nov 17, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Acute Myeloid Leukemia and is currently completed. Cardiff Oncology leads this study, which shows 25 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jun 2020 · 7 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Dec 2021 · 6 months · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Mar 2023 · 8 months · monthly snapshot~Mar 2023 – ~Jul 2024 · 16 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Mar 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  4. Jul 2022 — Mar 2023 [monthly]

    Completed PHASE1_PHASE2

  5. Feb 2022 — Jul 2022 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

▶ Show 20 earlier versions

  1. Dec 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Jun 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Mar 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  7. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE1_PHASE2

  8. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  9. Nov 2019 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  10. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1_PHASE2

  11. Jul 2019 — Oct 2019 [monthly]

    Recruiting PHASE1_PHASE2

  12. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  13. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jan 2019 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  15. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE1_PHASE2

  16. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1_PHASE2

  17. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE1_PHASE2

  18. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  19. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet Recruiting → Recruiting

  20. Oct 2017 — Dec 2017 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cardiff Oncology
Data source: Cardiff Oncology

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations