deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 4-arm NCT03307616

Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery

Phase II Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma

Sponsor: M.D. Anderson Cancer Center

Conditions Dedifferentiated Liposarcoma Recurrent Dedifferentiated Liposarcoma Recurrent Undifferentiated Pleomorphic Sarcoma Resectable Dedifferentiated Liposarcoma Resectable Undifferentiated Pleomorphic Sarcoma Undifferentiated Pleomorphic Sarcoma
Interventions Ipilimumab Nivolumab Radiation Therapy
Updated 26 times since 2017 Last updated: Mar 3, 2026 Started: Oct 4, 2017 Primary completion: Oct 31, 2027 Completion: Oct 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03307616, this PHASE2 trial focuses on Dedifferentiated Liposarcoma and Recurrent Dedifferentiated Liposarcoma and remains ongoing. Sponsored by M.D. Anderson Cancer Center, it has been updated 26 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~May 2019 · 4 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Nov 2019 · 5 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Apr 2020 · 3 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2022 · 14 months · monthly snapshot~Mar 2022 – ~Mar 2023 · 12 months · monthly snapshot~Mar 2023 – ~Oct 2023 · 7 months · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~May 2024 · 5 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~May 2025 · 6 months · monthly snapshot~May 2025 – ~Oct 2025 · 5 months · monthly snapshot~Oct 2025 – ~Mar 2026 · 5 months · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

26 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Oct 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. May 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Nov 2024 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 21 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Dec 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  6. Mar 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Jan 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE2

  8. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  9. Sep 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  10. Apr 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  11. Jan 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  12. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  13. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  14. Jun 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  15. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  16. Jan 2019 — May 2019 [monthly]

    Recruiting PHASE2

  17. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  18. Aug 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  19. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  20. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  21. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations