deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT03318939

Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation

A Phase 2 Study of Poziotinib in Patients With Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, With EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20)

Sponsor: Spectrum Pharmaceuticals, Inc

Conditions NSCLC
Interventions Poziotinib
Updated 32 times since 2017 Last updated: Apr 1, 2024 Started: Oct 13, 2017 Primary completion: Apr 3, 2023 Completion: Apr 3, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Strategic business decision (unrelated to safety)

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This PHASE2 trial investigates NSCLC and is currently terminated or withdrawn. Spectrum Pharmaceuticals, Inc leads this study, which shows 32 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~May 2019 · 3 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Mar 2020 · 7 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Sep 2020 · 4 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Feb 2022 · 4 months · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Feb 2023 · 11 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Feb 2024 · 11 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

32 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. May 2024 — Jul 2024 [monthly]

    Terminated PHASE2

  5. Feb 2024 — May 2024 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

▶ Show 27 earlier versions

  1. Mar 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Mar 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  4. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  5. Oct 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  6. Jun 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  7. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  8. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  9. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  10. May 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  11. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  12. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  13. Aug 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  14. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  15. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  16. Feb 2019 — May 2019 [monthly]

    Recruiting PHASE2

  17. Oct 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  18. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  19. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  20. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  21. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  22. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE2

  23. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  24. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  25. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE2

  26. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

  27. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

    First recorded

Oct 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Spectrum Pharmaceuticals, Inc
Data source: Spectrum Pharmaceuticals, Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Arcadia, United States , Athens, United States , Austin, United States , Baltimore, United States , Barcelona, Spain , Beersheba, Israel , Boston, United States , Boulder, United States , Brussels, Belgium , Buffalo, United States and 50 more locations