deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03321513

DRCR.Net Aflibercept vs. Bevacizumab + Deferred Aflibercept for the Treatment of CI-DME (DRCR AC)

Randomized Trial of Intravitreous Aflibercept Versus Intravitreous Bevacizumab + Deferred Aflibercept for Treatment of Central-Involved Diabetic Macular Edema

Sponsor: Jaeb Center for Health Research

Conditions Diabetic Macular Edema
Interventions Bevacizumab + Deferred Aflibercept Group intravitreous aflibercept
Updated 27 times since 2017 Last updated: Apr 24, 2024 Started: Dec 7, 2017 Primary completion: Dec 22, 2021 Completion: Dec 22, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Diabetic Macular Edema and is currently completed. Jaeb Center for Health Research leads this study, which shows 27 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Nov 2017 – ~Jan 2018 · 2 months · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Feb 2019 · 3 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Feb 2022 · 10 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~May 2024 · 17 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. May 2024 — Jul 2024 [monthly]

    Completed PHASE3

  5. Dec 2022 — May 2024 [monthly]

    Completed PHASE3

▶ Show 22 earlier versions

  1. Jul 2022 — Dec 2022 [monthly]

    Completed PHASE3

  2. Feb 2022 — Jul 2022 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  3. Apr 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  6. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  7. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  8. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  9. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  10. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  11. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  12. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE3

  13. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  14. Nov 2018 — Feb 2019 [monthly]

    Recruiting PHASE3

  15. Sep 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  16. Jul 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  17. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  18. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  19. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  20. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  21. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  22. Nov 2017 — Jan 2018 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Jaeb Center for Health Research
Data source: Jaeb Center for Health Research

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Asheville, United States , Augusta, United States , Austin, United States , Ayer, United States , Boston, United States , Campbell, United States , Charlotte, United States , Cleveland, United States , Fort Myers, United States and 38 more locations