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Completed PHASE2 INTERVENTIONAL 4-arm NCT03329690

DS-8201a in Human Epidermal Growth Factor Receptor 2 (HER2)-Expressing Gastric Cancer [DESTINY-Gastric01]

A Phase 2, Multicenter, Open-label Study of DS-8201a in Subjects With HER2-expressing Advanced Gastric or Gastroesophageal Junction Adenocarcinoma

Sponsor: AstraZeneca

Conditions Neoplasm, Gastrointestinal
Interventions DS-8201a Physician's Choice
Updated 29 times since 2017 Last updated: Mar 17, 2022 Started: Nov 2, 2017 Primary completion: Nov 8, 2019 Completion: Dec 11, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03329690, this PHASE2 trial focuses on Neoplasm, Gastrointestinal and remains completed. Sponsored by AstraZeneca, it has been updated 29 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~May 2018 · 3 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Oct 2020 · 9 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jan 2022 · 10 months · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Mar 2024 · 23 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

29 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Mar 2024 — Jul 2024 [monthly]

    Completed PHASE2

  5. Apr 2022 — Mar 2024 [monthly]

    Completed PHASE2

▶ Show 24 earlier versions

  1. Mar 2022 — Apr 2022 [monthly]

    Completed PHASE2

  2. Jan 2022 — Mar 2022 [monthly]

    Completed PHASE2

  3. Mar 2021 — Jan 2022 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  6. Oct 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE2

  7. Jan 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

  8. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2

  9. Aug 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE2

  10. Jul 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  11. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  12. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  13. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  14. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  15. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  16. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  17. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  18. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  19. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  20. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  21. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  22. Feb 2018 — May 2018 [monthly]

    Recruiting PHASE2

  23. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE2

  24. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

    First recorded

Nov 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • Daiichi Sankyo Co., Ltd.
Data source: Daiichi Sankyo

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akashi, Japan , Amagasaki, Japan , Bunkyō-Ku, Japan , Busan, South Korea , Cheongju-si, South Korea , Chiba, Japan , Chuo Ku, Japan , Daegu, South Korea , Fukui, Japan , Fukuoka, Japan and 39 more locations