deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT03341078

Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users (Ibudilast)

Brain Function and Connectivity in Methamphetamine Dependence: The Link to Neuroinflammation and the Effects of Ibudilast

Sponsor: Oregon Health and Science University

Conditions Methamphetamine-dependence
Interventions Ibudilast Placebo Oral Tablet
Updated 21 times since 2017 Last updated: Jan 28, 2026 Started: May 1, 2019 Primary completion: Oct 15, 2025 Completion: Oct 15, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03341078, this PHASE2 trial focuses on Methamphetamine-dependence and remains completed. Sponsored by Oregon Health and Science University, it has been updated 21 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Feb 2019 · 6 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Mar 2020 · 5 months · monthly snapshot~Mar 2020 – ~Aug 2020 · 5 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Feb 2022 · 8 months · monthly snapshot~Feb 2022 – ~Jan 2023 · 11 months · monthly snapshot~Jan 2023 – ~Aug 2023 · 7 months · monthly snapshot~Aug 2023 – ~Feb 2024 · 6 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshot~Aug 2025 – ~Feb 2026 · 6 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

21 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE2

    Status: Recruiting → Completed

  2. Aug 2025 — Feb 2026 [monthly]

    Recruiting PHASE2

  3. Sep 2024 — Aug 2025 [monthly]

    Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

▶ Show 16 earlier versions

  1. Feb 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  2. Aug 2023 — Feb 2024 [monthly]

    Recruiting PHASE2

  3. Jan 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  4. Feb 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  5. Jun 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  6. Jan 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  7. Aug 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  8. Mar 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  9. Oct 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  10. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  11. Jun 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  12. Apr 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE2

  13. Feb 2019 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE2

  14. Aug 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE2

  15. Jun 2018 — Aug 2018 [monthly]

    Not Yet Recruiting PHASE2

  16. Dec 2017 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Oregon Health and Science University
  • Portland VA Medical Center
  • VA Office of Research and Development
Data source: VA Office of Research and Development

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations