deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT03370276

Cetuximab & Nivolumab in Patients With Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

A Phase I/II Study of Concurrent Cetuximab and Nivolumab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Sponsor: Bristol-Myers Squibb

Conditions Head and Neck Carcinoma Head and Neck Squamous Cell Carcinoma Squamous Cell Cancer Squamous Cell Carcinoma of the Hypopharynx Squamous Cell Carcinoma of the Larynx Squamous Cell Carcinoma of the Oral Cavity Squamous Cell Carcinoma of the Oropharynx Squamous Cell Carcinoma of the Paranasal Sinus
Interventions Cetuximab Nivolumab
Updated 34 times since 2017 Last updated: Feb 25, 2026 Started: Dec 20, 2017 Primary completion: Sep 4, 2021 Completion: Dec 23, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Head and Neck Carcinoma and Head and Neck Squamous Cell Carcinoma, this trial is completed. The trial is conducted by Bristol-Myers Squibb and has accumulated 34 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Dec 2017 – ~May 2018 · 5 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Mar 2019 · 5 months · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jun 2020 · 5 months · monthly snapshot~Jun 2020 – ~Dec 2020 · 6 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Oct 2021 · 5 months · monthly snapshot~Oct 2021 – ~Mar 2022 · 5 months · monthly snapshot~Mar 2022 – ~Sep 2022 · 6 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Jun 2023 · 4 months · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 6 months · monthly snapshot

Change History

34 versions recorded

  1. Mar 2026 — Present [monthly]

    Completed PHASE1/PHASE2

    Status: Active Not Recruiting → Completed

  2. Jan 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  5. Jul 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

▶ Show 29 earlier versions

  1. Apr 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. Jan 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Oct 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  6. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  7. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. Nov 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Jun 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Feb 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  12. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  13. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  14. Mar 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  15. Oct 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  16. May 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  17. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  18. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jun 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  20. Jan 2020 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  21. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1_PHASE2

  22. Aug 2019 — Dec 2019 [monthly]

    Recruiting PHASE1_PHASE2

  23. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1_PHASE2

  24. Mar 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  25. Oct 2018 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  26. Jul 2018 — Oct 2018 [monthly]

    Recruiting PHASE1_PHASE2

  27. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  28. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  29. Dec 2017 — May 2018 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • H. Lee Moffitt Cancer Center and Research Institute
  • James and Esther King Biomedical Research Program
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations