deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT03383458

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (CheckMate 9DX)

A Phase 3, Randomized, Double-blind Study of Adjuvant Nivolumab Versus Placebo for Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Sponsor: Bristol-Myers Squibb

Updated 46 times since 2018 Last updated: Nov 18, 2025 Started: Apr 18, 2018 Primary completion: Feb 27, 2026 Completion: Feb 27, 2031
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Hepatocellular Carcinoma and Liver Cancer, this trial is ongoing. The trial is conducted by Bristol-Myers Squibb and has accumulated 46 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Jun 2019 · 4 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Nov 2021 · 8 months · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Aug 2023 · 6 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

46 versions recorded
  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Dec 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

Show 41 earlier versions
  1. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Feb 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  7. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  8. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  9. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  10. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  11. Apr 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  12. Nov 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  13. Mar 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  14. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  15. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  16. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  17. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  18. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  19. Apr 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  20. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  21. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  22. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE3

  23. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  24. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  25. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  26. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  27. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  28. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  29. Feb 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  30. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  31. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  32. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  33. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  34. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  35. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  36. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  37. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  38. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  39. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE3

  40. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  41. Jan 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • Ono Pharmaceutical Co. Ltd
Data source: Bristol-Myers Squibb

For direct contact, visit the study record on ClinicalTrials.gov .