deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 3-arm NCT03389230

Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

Phase I Study of Cellular Immunotherapy Using Memory-Enriched T Cells Lentivirally Transduced to Express a HER2-Specific, Hinge-Optimized, 41BB-Costimulatory Chimeric Receptor and a Truncated CD19 for Patients With Recurrent/Refractory Malignant Glioma

Sponsor: City of Hope Medical Center

Conditions Glioblastoma Malignant Glioma Recurrent Glioma Refractory Glioma WHO Grade III Glioma
Interventions HER2(EQ)BBζ/CD19t+ T cells Laboratory Biomarker Analysis Leukapheresis
Updated 21 times since 2018 Last updated: Feb 2, 2026 Started: Aug 14, 2018 Primary completion: Dec 29, 2026 Completion: Dec 29, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Glioblastoma and Malignant Glioma, this trial is ongoing. The trial is conducted by City of Hope Medical Center and has accumulated 21 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~May 2019 · 8 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~May 2020 · 10 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Feb 2024 · 7 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Aug 2025 · 6 months · monthly snapshot~Aug 2025 – ~Feb 2026 · 6 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

21 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Aug 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Feb 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 16 earlier versions

  1. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jul 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  3. Sep 2022 — Jul 2023 [monthly]

    Recruiting PHASE1

  4. Sep 2021 — Sep 2022 [monthly]

    Recruiting PHASE1

  5. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  6. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  7. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  8. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  9. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  10. Jul 2019 — May 2020 [monthly]

    Recruiting PHASE1

  11. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  12. Sep 2018 — May 2019 [monthly]

    Recruiting PHASE1

  13. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  14. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  15. Jun 2018 — Jul 2018 [monthly]

    Not Yet Recruiting PHASE1

  16. Jan 2018 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • City of Hope Medical Center
  • National Cancer Institute (NCI)
Data source: City of Hope Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations