deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 5-arm NCT03397264

A Dose Ranging Study of OPT-302 With Aflibercept for Persistent Diabetic Macular Edema

Phase 1b/2a Study of OPT-302 in Combination With Aflibercept for Persistent Central-involved Diabetic Macular Edema

Sponsor: Opthea Limited

Updated 14 times since 2018 Last updated: Apr 15, 2025 Started: Jan 16, 2018 Primary completion: Mar 26, 2020 Completion: Jun 11, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Diabetic Macular Edema, this trial is completed. The trial is conducted by Opthea Limited and has accumulated 14 data snapshots since 2018. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~Oct 2019 · 7 months · monthly snapshot~Oct 2019 – ~Apr 2020 · 6 months · monthly snapshot~Apr 2020 – ~Dec 2020 · 8 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jul 2022 · 10 months · monthly snapshot~Jul 2022 – ~Jul 2024 · 24 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

14 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Sep 2024 — May 2025 [monthly]

    Completed PHASE1/PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  5. Jul 2022 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

Show 9 earlier versions
  1. Sep 2021 — Jul 2022 [monthly]

    Completed PHASE1_PHASE2

  2. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE1_PHASE2

  3. Dec 2020 — Jan 2021 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not RecruitingCompleted

  4. Apr 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: RecruitingActive Not Recruiting

  5. Oct 2019 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  6. Mar 2019 — Oct 2019 [monthly]

    Recruiting PHASE1_PHASE2

  7. Dec 2018 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  8. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE1_PHASE2

  9. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Jan 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Opthea Limited
Data source: Opthea Limited

For direct contact, visit the study record on ClinicalTrials.gov .