deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT03401788

A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

An Open-Label Phase 2 Study to Evaluate PT2977 for the Treatment of Von Hippel Lindau Disease-Associated Renal Cell Carcinoma

Sponsor: Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

Interventions Belzutifan
Updated 27 times since 2018 Last updated: Nov 28, 2024 Started: May 2, 2018 Primary completion: Mar 29, 2026 Completion: Mar 29, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on VHL - Von Hippel-Lindau Syndrome and VHL Gene Inactivation, this trial is ongoing. The trial is conducted by Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) and has accumulated 27 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Jun 2020 · 11 months · monthly snapshot~Jun 2020 – ~Nov 2020 · 5 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2024 · 13 months · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – present · 19 months · monthly snapshot

Change History

27 versions recorded
  1. Jan 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

Show 22 earlier versions
  1. Jan 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2022 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  6. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  8. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE2

  9. Jun 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

  10. Jul 2019 — Jun 2020 [monthly]

    Active Not Recruiting PHASE2

  11. Mar 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE2

  12. Feb 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  13. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  14. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  15. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  16. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  17. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  18. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  19. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  20. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  21. Mar 2018 — Apr 2018 [monthly]

    Not Yet Recruiting PHASE2

  22. Feb 2018 — Mar 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Data source: Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

For direct contact, visit the study record on ClinicalTrials.gov .