deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT03452111

Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

Clinical Evaluation of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Conditions Healthy Male Contraception Men
Interventions Nestorone + Testosterone Combination Gel
Updated 17 times since 2018 Last updated: Feb 14, 2025 Started: Oct 25, 2018 Primary completion: Sep 6, 2024 Completion: Sep 6, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03452111, this PHASE2 trial focuses on Healthy and Male Contraception and remains completed. Sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), it has been updated 17 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Dec 2018 · 4 months · monthly snapshot~Dec 2018 – ~Jan 2021 · 25 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Jan 2023 · 11 months · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~Sep 2023 · 5 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Nov 2025 · 8 months · monthly snapshot~Nov 2025 – present · 9 months · monthly snapshot

Change History

17 versions recorded

  1. Nov 2025 — Present [monthly]

    Completed PHASE2

  2. Mar 2025 — Nov 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Oct 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 12 earlier versions

  1. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

  2. Apr 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Feb 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  5. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  6. Sep 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  7. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE2

  9. Dec 2018 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  10. Aug 2018 — Dec 2018 [monthly]

    Not Yet Recruiting PHASE2

  11. Jun 2018 — Aug 2018 [monthly]

    Not Yet Recruiting PHASE2

  12. Mar 2018 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  • Population Council
  • Premier Research
Data source: Premier Research

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Bologna, Italy , Denver, United States , Edinburgh, United Kingdom , Harare, Zimbabwe , Kansas City, United States , Manchester, United Kingdom , Nairobi, Kenya , Norfolk, United States , Philadelphia, United States , Portland, United States and 6 more locations