deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03464136

Safety and Efficacy of Adalimumab Versus Ustekinumab for One Year (SEAVUE)

A Phase 3b, Multicenter, Randomized, Blinded, Active-Controlled Study to Compare the Efficacy and Safety of Ustekinumab to That of Adalimumab in the Treatment of Biologic Naïve Subjects With Moderately-to-Severely Active Crohn's Disease

Sponsor: Janssen Scientific Affairs, LLC

Conditions Crohn Disease
Updated 50 times since 2018 Last updated: Apr 25, 2025 Started: Mar 29, 2018 Primary completion: Dec 15, 2020 Completion: May 21, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Crohn Disease and is currently completed. Janssen Scientific Affairs, LLC leads this study, which shows 50 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Jul 2023 · 12 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

50 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Apr 2025 — May 2025 [monthly]

    Completed PHASE3

  4. Mar 2025 — Apr 2025 [monthly]

    Completed PHASE3

  5. Sep 2024 — Mar 2025 [monthly]

    Completed PHASE3

Show 45 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  2. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE3

  3. Jul 2022 — Jul 2023 [monthly]

    Completed PHASE3

  4. Feb 2022 — Jul 2022 [monthly]

    Completed PHASE3

  5. Sep 2021 — Feb 2022 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  6. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  7. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  8. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  9. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  10. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  11. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE3

  12. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  13. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  14. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  15. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  16. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  17. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  18. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  19. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  20. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  21. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  22. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  23. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  24. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  25. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  26. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  27. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  28. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  29. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  30. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  31. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  32. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  33. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  34. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  35. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  36. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  37. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  38. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  39. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  40. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  41. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  42. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  43. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  44. Apr 2018 — May 2018 [monthly]

    Not Yet Recruiting PHASE3

  45. Mar 2018 — Apr 2018 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Scientific Affairs, LLC
Data source: Janssen Scientific Affairs, LLC

For direct contact, visit the study record on ClinicalTrials.gov .