deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT03498521

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)

A Phase II, Randomized, Active-Controlled, Multi-Center Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Guided by Genomic Profiling Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site Who Have Received Three Cycles of Platinum Doublet Chemotherapy

Sponsor: Foundation Medicine

Conditions Cancer of Unknown Primary Site
Interventions Alectinib Atezolizumab Bevacizumab Carboplatin Cisplatin Cobimetinib Entrectinib Erlotinib Gemcitabine Ipatasertib Ivosidenib Olaparib Paclitaxel Pemigatinib Pertuzumab Trastuzumab Subcutaneous (SC) Vemurafenib Vismodegib
Updated 65 times since 2018 Last updated: Nov 6, 2025 Started: Jul 10, 2018 Primary completion: Feb 14, 2023 Completion: Nov 7, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03498521, this PHASE2 trial focuses on Cancer of Unknown Primary Site and remains completed. Sponsored by Foundation Medicine, it has been updated 65 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

65 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Mar 2025 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 60 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  7. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  8. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  9. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  10. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  11. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  12. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  13. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  14. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  15. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  16. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  17. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  18. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  19. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  20. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  21. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  22. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  23. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  24. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  25. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  26. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  27. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  28. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  29. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  30. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  31. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  32. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  33. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  34. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  35. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  36. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  37. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  38. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  39. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  40. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  41. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  42. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  43. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  44. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  45. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  46. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  47. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  48. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  49. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  50. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  51. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  52. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  53. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  54. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  55. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  56. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  57. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  58. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  59. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  60. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Foundation Medicine
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarhus N, Denmark , Adana, Turkey (Türkiye) , Aichi, Japan , Angers, France , Ankara, Turkey (Türkiye) , Antalya, Turkey (Türkiye) , Athens, Greece , Augsburg, Germany , Bangkok, Thailand , Barcelona, Spain and 104 more locations