deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 5-arm NCT03503968

TCR Modified T Cells MDG1011 in High Risk Myeloid and Lymphoid Neoplasms

A Phase I/II, Open-Label, Non-Randomized, Multicentre, Dose-Escalation Clinical Trial With Control Group to Evaluate the Safety, Feasibility and Preliminary Efficacy of PRAME TCR Modified T Cells, MDG1011, in Subjects With High Risk Myeloid and Lymphoid Neoplasms

Sponsor: Medigene AG

Updated 11 times since 2018 Last updated: Feb 13, 2023 Started: Mar 27, 2018 Primary completion: Jun 28, 2022 Completion: Jul 15, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The clinical trial is terminated after the completion of phase I without moving to Phase II.

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A PHASE1/PHASE2 clinical study on Feasibility and Safety, this trial is terminated or withdrawn. The trial is conducted by Medigene AG and has accumulated 11 data snapshots since 2018. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~May 2018 – ~Jun 2018 · 31 days · monthly snapshotRecruiting~Jun 2018 – ~Apr 2019 · 10 months · monthly snapshotRecruiting~Apr 2019 – ~Aug 2019 · 4 months · monthly snapshotRecruiting~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshotRecruiting~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshotRecruiting~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshotRecruiting~Jan 2021 – ~Mar 2023 · 26 months · monthly snapshotRecruiting~Mar 2023 – ~Jul 2024 · 16 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotTerminated~Sep 2025 – present · 10 months · monthly snapshotTerminated

Change History

11 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  4. Mar 2023 — Jul 2024 [monthly]

    Terminated PHASE1_PHASE2

    Status: RecruitingTerminated

  5. Jan 2021 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

Show 6 earlier versions
  1. Feb 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  2. Nov 2019 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  3. Aug 2019 — Nov 2019 [monthly]

    Recruiting PHASE1_PHASE2

  4. Apr 2019 — Aug 2019 [monthly]

    Recruiting PHASE1_PHASE2

  5. Jun 2018 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  6. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Mar 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Medigene AG
Data source: Medigene AG

For direct contact, visit the study record on ClinicalTrials.gov .