deltatrials
Active Not Recruiting PHASE4 INTERVENTIONAL 3-arm NCT03535298

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS (DELIVER-MS)

Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for the Treatment of Relapsing-Remitting Multiple Sclerosis

Sponsor: The Cleveland Clinic

Conditions Multiple Sclerosis, Relapsing-Remitting
Interventions Early Highly Effective Therapies Group Escalation Therapies Group
Updated 16 times since 2018 Last updated: Aug 22, 2025 Started: Jan 3, 2019 Primary completion: Jul 30, 2027 Completion: Jul 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03535298, this PHASE4 trial focuses on Multiple Sclerosis, Relapsing-Remitting and remains ongoing. Sponsored by The Cleveland Clinic, it has been updated 16 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~Sep 2019 · 7 months · monthly snapshot~Sep 2019 – ~Apr 2020 · 7 months · monthly snapshot~Apr 2020 – ~Jan 2021 · 9 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Jun 2024 · 9 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

16 versions recorded

  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE4

  2. Sep 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE4

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE4

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE4

  5. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

▶ Show 11 earlier versions

  1. Sep 2023 — Jun 2024 [monthly]

    Recruiting PHASE4

  2. Sep 2022 — Sep 2023 [monthly]

    Recruiting PHASE4

  3. Sep 2021 — Sep 2022 [monthly]

    Recruiting PHASE4

  4. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE4

  5. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE4

  6. Apr 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

  7. Sep 2019 — Apr 2020 [monthly]

    Recruiting PHASE4

  8. Feb 2019 — Sep 2019 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  9. Oct 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE4

  10. Jul 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE4

  11. Jun 2018 — Jul 2018 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • The Cleveland Clinic
  • University of Nottingham
Data source: The Cleveland Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Austin, United States , Buffalo, United States , Cardiff, United Kingdom , Charlottesville, United States , Cincinnati, United States , Cleveland, United States , Columbus, United States , Coventry, United Kingdom , Edinburgh, United Kingdom and 17 more locations