deltatrials
Terminated PHASE1 INTERVENTIONAL 3-arm NCT03539484

A Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors

A First-in-Human, Open-Label, Multicenter, Dose-Escalation Phase I Clinical Study of Single-Agent RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors

Sponsor: Hoffmann-La Roche

Conditions Solid Tumors
Interventions Obinutuzumab RO7172508 Tocilizumab
Updated 26 times since 2018 Last updated: Aug 17, 2020 Started: Jul 4, 2018 Primary completion: Jul 22, 2019 Completion: Jul 22, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study terminated due to change in benefit-risk ratio, driven by high incidence GI toxicity in absence of clinically significant anti-tumor efficacy.

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This PHASE1 trial investigates Solid Tumors and is currently terminated or withdrawn. Hoffmann-La Roche leads this study, which shows 26 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Mar 2020 · 4 months · monthly snapshot~Mar 2020 – ~Oct 2020 · 7 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Jul 2024 · 28 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

26 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  4. Mar 2022 — Jul 2024 [monthly]

    Terminated PHASE1

  5. Jan 2022 — Mar 2022 [monthly]

    Terminated PHASE1

▶ Show 21 earlier versions

  1. Dec 2021 — Jan 2022 [monthly]

    Terminated PHASE1

  2. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE1

  3. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE1

  4. Oct 2020 — Nov 2020 [monthly]

    Terminated PHASE1

    Status: Completed → Terminated

  5. Mar 2020 — Oct 2020 [monthly]

    Completed PHASE1

  6. Nov 2019 — Mar 2020 [monthly]

    Completed PHASE1

    Status: Terminated → Completed

  7. Sep 2019 — Nov 2019 [monthly]

    Terminated PHASE1

    Status: Recruiting → Terminated

  8. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  9. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  10. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  11. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  12. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  13. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  14. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  15. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  16. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  17. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  18. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  19. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  20. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  21. Jun 2018 — Aug 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations