Completed PHASE3 INTERVENTIONAL 2-arm NCT03541668

Study of rhPro-UK in Patients With Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset(PROST)

A Phase III Trial to Assess the Efficacy and Safety of Recombinant Human Prourokinase in the Treatment of Acute Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset

Sponsor: Tasly Biopharmaceuticals Co., Ltd.

Conditions Acute Ischaemic Stroke

Interventions Alteplase Recombinant human urokinase

Updated 8 times since 2018 Last updated: Jun 18, 2020 Started: May 18, 2018 Primary completion: Apr 14, 2020 Completion: May 24, 2020

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Acute Ischaemic Stroke and is currently completed. Tasly Biopharmaceuticals Co., Ltd. leads this study, which shows 8 recorded versions since 2018 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

8 versions recorded

Dec 2025 — Present [monthly]

Completed PHASE3
Sep 2025 — Dec 2025 [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3

▶ Show 3 earlier versions

Jul 2020 — Jan 2021 [monthly]

Completed PHASE3

Status: Recruiting → Completed
Feb 2019 — Jul 2020 [monthly]

Recruiting PHASE3
Jun 2018 — Feb 2019 [monthly]

Recruiting PHASE3

First recorded

May 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Tasly Biopharmaceuticals Co., Ltd.

Data source: Tasly Biopharmaceuticals Co., Ltd.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baotou, China , Beijing, China , Cangzhou, China , Changchun, China , Changsha, China , Chengdu, China , Dalian, China , Daqing, China , Deyang, China , Handan, China and 17 more locations