deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT03560973

A Double Blind, Placebo Controlled, Randomized Phase II Study Evaluating Gemcitabine With or Without Ramucirumab , for II Line Treatment MPM (RAMES)

A Double-blind, Placebo Controlled, Randomized Multicenter Phase II Study Evaluating Gemcitabine With or Without Ramucirumab as II Line Treatment for Advanced Malignant Pleural Mesothelioma

Sponsor: Gruppo Oncologico Italiano di Ricerca Clinica

Conditions Mesothelioma
Interventions Gemcitabine Ramucirumab
Updated 9 times since 2018 Last updated: Mar 11, 2025 Started: Dec 22, 2016 Primary completion: Jul 30, 2018 Completion: Jul 20, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Mesothelioma and is currently completed. Gruppo Oncologico Italiano di Ricerca Clinica leads this study, which shows 9 recorded versions since 2016 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshotRecruiting~Sep 2018 – ~Mar 2019 · 6 months · monthly snapshotActive Not Recruiting~Mar 2019 – ~Aug 2020 · 17 months · monthly snapshotActive Not Recruiting~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Sep 2022 · 20 months · monthly snapshotActive Not Recruiting~Sep 2022 – ~Jul 2024 · 22 months · monthly snapshotUnknown Status~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotUnknown~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotUnknown~Apr 2025 – present · 15 months · monthly snapshotCompleted

Change History

9 versions recorded

  1. Apr 2025 — Present [monthly]

    Completed PHASE2

    Status: Unknown → Completed

  2. Sep 2024 — Apr 2025 [monthly]

    Unknown PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Unknown PHASE2

    Status: Unknown Status → Unknown

  4. Sep 2022 — Jul 2024 [monthly]

    Unknown Status PHASE2

    Status: Active Not Recruiting → Unknown Status

  5. Jan 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

▶ Show 4 earlier versions

  1. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  2. Mar 2019 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Jul 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

    First recorded

Dec 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Gruppo Oncologico Italiano di Ricerca Clinica
Data source: Gruppo Oncologico Italiano di Ricerca Clinica

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations