Terminated PHASE3 INTERVENTIONAL 2-arm NCT03561090

A Trial of IW-3718 for 8 Weeks in Patients With Persistent Gastroesophageal Reflux Disease (GERD) Receiving Proton Pump Inhibitors (PPIs)

A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial of Oral IW-3718 Administered to Patients With Gastroesophageal Reflux Disease While Receiving Proton Pump Inhibitors

Sponsor: Ironwood Pharmaceuticals, Inc.

Conditions Gastroesophageal Reflux Disease (GERD)

Interventions IW-3718 Standard-dose PPIs QD placebo

Updated 12 times since 2018 Last updated: Aug 17, 2021 Started: Jun 20, 2018 Primary completion: Oct 7, 2020 Completion: Nov 3, 2020

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Parallel IW-3718 Phase III trial did not meet pre-specified criteria.

Other terminated trials from Ironwood Pharmaceuticals, Inc.

More terminations from Ironwood Pharmaceuticals, Inc.

Other Gastroesophageal Reflux Disease (GERD) trials with similar outcome

NCT00857597 · Phase PHASE3 · Dec 2011

Browse all Gastroesophageal Reflux Disease (GERD) trials

This PHASE3 trial investigates Gastroesophageal Reflux Disease (GERD) and is currently terminated or withdrawn. Ironwood Pharmaceuticals, Inc. leads this study, which shows 12 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

12 versions recorded

Sep 2025 — Present [monthly]

Terminated PHASE3
Sep 2024 — Sep 2025 [monthly]

Terminated PHASE3
Jul 2024 — Sep 2024 [monthly]

Terminated PHASE3
Sep 2021 — Jul 2024 [monthly]

Terminated PHASE3
Jan 2021 — Sep 2021 [monthly]

Terminated PHASE3

Status: Recruiting → Terminated

▶ Show 7 earlier versions

Jul 2020 — Jan 2021 [monthly]

Recruiting PHASE3
Jun 2020 — Jul 2020 [monthly]

Recruiting PHASE3
Aug 2019 — Jun 2020 [monthly]

Recruiting PHASE3
Feb 2019 — Aug 2019 [monthly]

Recruiting PHASE3
Nov 2018 — Feb 2019 [monthly]

Recruiting PHASE3
Sep 2018 — Nov 2018 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
Jul 2018 — Sep 2018 [monthly]

Not Yet Recruiting PHASE3

First recorded

Jun 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Ironwood Pharmaceuticals, Inc.

Data source: Ironwood Pharmaceuticals, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Anaheim, United States , Anniston, United States , Aurora, United States , Baltimore, United States , Bellevue, United States , Boston, United States , Bridgeport, United States , Bristol, United States , Chattanooga, United States and 77 more locations