deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT03573310

A Study of JNJ-64619178, an Inhibitor of PRMT5 in Participants With Advanced Solid Tumors, NHL, and Lower Risk MDS

A Phase 1, First-in-Human, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-64619178, an Inhibitor of Protein Arginine Methyltransferase 5 (PRMT5) in Subjects With Advanced Cancers

Sponsor: Janssen Research & Development, LLC

Conditions Myelodysplastic Syndromes Neoplasms Non-Hodgkin Lymphoma Solid Tumor, Adult
Interventions JNJ-64619178
Updated 67 times since 2018 Last updated: Dec 10, 2025 Started: Jul 13, 2018 Primary completion: Sep 25, 2025 Completion: Sep 25, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Myelodysplastic Syndromes and Neoplasms, this trial is completed. The trial is conducted by Janssen Research & Development, LLC and has accumulated 67 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Jun 2019 · 5 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Oct 2020 · 4 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – present · 4 months · monthly snapshot

Change History

67 versions recorded

  1. Jan 2026 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Oct 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 62 earlier versions

  1. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  2. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  6. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  7. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

  8. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  9. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  10. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  11. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  12. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  13. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  14. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  15. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  16. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  17. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  18. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  19. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  20. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  21. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  22. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  23. Jun 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  24. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  25. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  26. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  27. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  28. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  29. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  30. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  31. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

  32. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  33. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  34. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  35. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  36. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  37. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  38. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  39. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  40. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  41. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  42. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  43. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  44. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  45. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  46. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  47. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  48. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  49. Jun 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  50. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  51. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  52. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  53. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  54. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  55. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  56. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  57. Jul 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  58. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  59. Jan 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  60. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  61. Aug 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  62. Jul 2018 — Aug 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Badalona, Spain , Barcelona, Spain , Boston, United States , Columbus, United States , Düsseldorf, Germany , Frankfurt am Main, Germany , Haifa, Israel , Houston, United States , Jerusalem, Israel , Leipzig, Germany and 8 more locations