deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT03573999

Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation

Effect of Isosmotic Doses of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation in Supratentorial Craniotomies

Sponsor: Aristotle University Of Thessaloniki

Updated 10 times since 2018 Last updated: May 5, 2021 Started: Jun 29, 2018 Primary completion: Oct 31, 2019 Completion: Dec 20, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Brain Edema and Electrolyte and Fluid Balance Conditions and is currently completed. Aristotle University Of Thessaloniki leads this study, which shows 10 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshotNot Yet Recruiting~Sep 2018 – ~Feb 2020 · 17 months · monthly snapshotRecruiting~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshotCompleted~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshotCompleted~Apr 2021 – ~May 2021 · 30 days · monthly snapshotCompleted~May 2021 – ~Jun 2021 · 31 days · monthly snapshotCompleted~Jun 2021 – ~Jul 2024 · 37 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 11 months · monthly snapshotCompleted

Change History

10 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE4

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE4

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  4. Jun 2021 — Jul 2024 [monthly]

    Completed PHASE4

  5. May 2021 — Jun 2021 [monthly]

    Completed PHASE4

Show 5 earlier versions
  1. Apr 2021 — May 2021 [monthly]

    Completed PHASE4

  2. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE4

  3. Feb 2020 — Jan 2021 [monthly]

    Completed PHASE4

    Status: RecruitingCompleted

  4. Sep 2018 — Feb 2020 [monthly]

    Recruiting PHASE4

    Status: Not Yet RecruitingRecruiting

  5. Jul 2018 — Sep 2018 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Jun 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Aristotle University Of Thessaloniki
Data source: Aristotle University Of Thessaloniki

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations