Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)
Selective High Frequency Oscillation Ventilation(HFOV) vs Conventional Mechanical Ventilation(CMV) for Neonates With Acute Respiratory Distress Syndrome(ARDS):an Multicenters Randomized Controlled Trial
Sponsor: Affiliated Hospital of Southwest Medical University
A NA clinical study on Acute Respiratory Distress Syndrome and Conventional Mechanical Ventilation, this trial is completed. The trial is conducted by Affiliated Hospital of Southwest Medical University and has accumulated 21 data snapshots since 2024. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Study Description(click to expand)Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracorporeal membrane oxygenation is used to neonates with severe ARDS. However, extracorporeal membrane oxygenation can also lead to high death rate and need more technique and conditions. Mechanical ventilation with higher parameters was a substitute for such situations, but the death rate, complications and injuries of higher parameters is unknown. The purpose of the present study was to compare HFOV with CMV as invasive respiratory support strategies on decrease the mortality and morbidities in neonate with ARDS.
Severe acute respiratory distress syndrome (ARDS) is one of the serious complications in critically ill neonates. It can result in severe hypoxemia refractory to mechanical ventilation. Usually, invasive ventilation with low parameters is enough for neonates with mild and moderate ARDS. And extracorporeal membrane oxygenation is used to neonates with severe ARDS. However, extracorporeal membrane oxygenation can also lead to high death rate and need more technique and conditions. Mechanical ventilation with higher parameters was a substitute for such situations, but the death rate, complications and injuries of higher parameters is unknown. The purpose of the present study was to compare HFOV with CMV as invasive respiratory support strategies on decrease the mortality and morbidities in neonate with ARDS.
Status Flow
Change History
21 versions recorded-
Sep 2025 — Present [monthly]
Completed NA
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Aug 2025 — Sep 2025 [monthly]
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Status: Withdrawn → Completed
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Mar 2025 — Aug 2025 [monthly]
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Feb 2025 — Mar 2025 [monthly]
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Nov 2024 — Feb 2025 [monthly]
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▶ Show 16 earlier versions
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Sep 2024 — Nov 2024 [monthly]
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Jul 2024 — Sep 2024 [monthly]
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Feb 2024 — Jul 2024 [monthly]
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Jun 2023 — Feb 2024 [monthly]
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Status: Recruiting → Withdrawn
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Apr 2023 — Jun 2023 [monthly]
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Feb 2023 — Apr 2023 [monthly]
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Nov 2022 — Feb 2023 [monthly]
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Oct 2021 — Nov 2022 [monthly]
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Jan 2021 — Mar 2021 [monthly]
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Sep 2020 — Jan 2021 [monthly]
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Aug 2019 — Sep 2020 [monthly]
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Apr 2019 — Aug 2019 [monthly]
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Jan 2019 — Apr 2019 [monthly]
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Dec 2018 — Jan 2019 [monthly]
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Aug 2018 — Dec 2018 [monthly]
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First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Affiliated Hospital of Southwest Medical University
- Beijing 302 Hospital
- Bethune International Peace Hospital
- Chengdu Women and Children's Center Hospital
- Children's Hospital of Chongqing Medical University
- Children's Hospital of Fudan University
- Children's Hospital of Nanjing Medical University
- Children's Hospital of The Capital Institute of Pediatrics
- Chongqing Maternal and Child Health Hospital
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- First Affiliated Hospital of Chongqing Medical University
- First Affiliated Hospital of Guangxi Medical University
- First Affiliated Hospital of Harbin Medical University
- First Affiliated Hospital of Kunming Medical University
- First Affiliated Hospital of Xinjiang Medical University
- First Hospital of Tsinghua University
- Gansu Provincial Maternal and Child Health Care Hospital
- Guangdong Academy of Medical Science and General Hospital
- Guangdong Women and Children Hospital
- Guiyang Maternal and Child Health Care Hospital
- Hunan Children's Hospital
- Inner Mongolia People's Hospital
- Jiangxi Province Children's Hospital
- Jiulongpo No.1 People's Hospital
- Kunming Children's Hospital
- LanZhou University
- Lanzhou University Second Hospital
- Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
- Maternal and Children's Healthcare Hospital of Taian
- Mianyang Central Hospital
- Nanjing Medical University
- Ningbo Women & Children's Hospital
- Peking University Third Hospital
- People's Hospital of Xinjiang Uygur Autonomous Region
- People's Liberation Army No.202 Hospital
- Qinhuangdao Maternal and Child Health Care Hospital
- Quanzhou Children's Hospital
- Second Affiliated Hospital of Guangzhou Medical University
- Shanghai Children's Medical Center
- Shanxi Provincial Maternity and Children's Hospital
- Shenzhen People's Hospital, The Second Medical College of Jinan University
- The Affiliated Hospital Of Southwest Medical University
- The Children's Hospital of Zhejiang University School of Medicine
- The First Affiliated Hospital of Anhui Medical University
- The First Affiliated Hospital of Zhengzhou University
- The First Hospital of Jilin University
- The First People's Hospital of Yinchuan
- The First People's Hospital of Yunnan
- The First People's Hospital of Zunyi
- The People's Hospital of Dehong Autonomous Prefecture
- The Second Hospital of Shandong University
- Third Affiliated Hospital of Zhengzhou University
- Tianjin Central Hospital of Gynecology Obstetrics
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Women and Children Hospital of Qinghai Province
- Women and Children's Health Hospital of Qujing
- Women and Children's Health Hospital of Yulin
- Women and Children's Hospital, Branch of Chongqing Sanxia Central Hospital
- Women's Hospital School Of Medicine Zhejiang University
- Xiamen Maternity & Child Care Hospital
- Xianyang Children's Hospital
- Xuzhou Children Hospital
- Yan'an Affiliated Hospital of Kunming Medical University
- Zhengzhou Children's Hospital, China
- Zhujiang Hospital
- the Maternal and Child Health Hospital of Hainan Province
For direct contact, visit the study record on ClinicalTrials.gov .