deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03605901

Dosing of Methadone for Spine Surgery

Sponsor: University of Florida

Conditions Pain, Postoperative
Interventions Aliquots of methadone titrated to apnea Standard dosing of methadone
Updated 18 times since 2018 Last updated: Jun 4, 2025 Started: Mar 19, 2019 Primary completion: May 9, 2025 Completion: May 9, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

PI left institution.

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This PHASE2 trial investigates Pain, Postoperative and is currently terminated or withdrawn. University of Florida leads this study, which shows 18 recorded versions since 2019 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Aug 2019 · 3 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Oct 2020 · 12 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Sep 2022 · 20 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Jun 2023 · 4 months · monthly snapshot~Jun 2023 – ~Jun 2024 · 12 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – present · 12 months · monthly snapshot

Change History

18 versions recorded

  1. Jul 2025 — Present [monthly]

    Terminated PHASE2

    Status: Recruiting → Terminated

  2. Sep 2024 — Jul 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

    Phase: EARLY_PHASE1 → PHASE2

  5. Jun 2023 — Jun 2024 [monthly]

    Recruiting EARLY_PHASE1

▶ Show 13 earlier versions

  1. Feb 2023 — Jun 2023 [monthly]

    Recruiting EARLY_PHASE1

  2. Sep 2022 — Feb 2023 [monthly]

    Recruiting EARLY_PHASE1

    Status: Completed → Recruiting

  3. Jan 2021 — Sep 2022 [monthly]

    Completed EARLY_PHASE1

  4. Oct 2020 — Jan 2021 [monthly]

    Completed EARLY_PHASE1

    Status: Recruiting → Completed

  5. Oct 2019 — Oct 2020 [monthly]

    Recruiting EARLY_PHASE1

  6. Aug 2019 — Oct 2019 [monthly]

    Recruiting EARLY_PHASE1

  7. May 2019 — Aug 2019 [monthly]

    Recruiting EARLY_PHASE1

    Status: Not Yet Recruiting → Recruiting

  8. Apr 2019 — May 2019 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  9. Mar 2019 — Apr 2019 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  10. Feb 2019 — Mar 2019 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  11. Dec 2018 — Feb 2019 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  12. Nov 2018 — Dec 2018 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  13. Aug 2018 — Nov 2018 [monthly]

    Not Yet Recruiting EARLY_PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of Florida
Data source: University of Florida

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations