deltatrials
Terminated PHASE4 INTERVENTIONAL 7-arm NCT03608163

Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF)

Sponsor: Albert Einstein College of Medicine

Conditions Diabetes Mellitus, Type 1 Hypoglycemia Hypoglycemia Unawareness
Interventions Diazoxide Naloxone Placebo (for Diazoxide) Placebo (for Naloxone)
Updated 18 times since 2018 Last updated: Aug 26, 2025 Started: Jan 8, 2019 Primary completion: Aug 22, 2019 Completion: Aug 22, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study suspended for a prolonged duration due to the Pandemic. Once research resumed project was streamlined due to insufficient resources. Study was sufficiently powered to conduct analysis for 2 of the arms. Remaining Aims were never initiated.

Other terminated trials from Albert Einstein College of Medicine

See all terminations from Albert Einstein College of Medicine

Other Diabetes Mellitus, Type 1 trials with similar outcome

Browse all Diabetes Mellitus, Type 1 trials

This PHASE4 trial investigates Diabetes Mellitus, Type 1 and Hypoglycemia and is currently terminated or withdrawn. Albert Einstein College of Medicine leads this study, which shows 18 recorded versions since 2019 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~Oct 2019 · 8 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jun 2020 · 5 months · monthly snapshot~Jun 2020 – ~Nov 2020 · 5 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Mar 2022 · 3 months · monthly snapshot~Mar 2022 – ~Apr 2023 · 13 months · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 11 months · monthly snapshot

Change History

18 versions recorded

  1. Oct 2025 — Present [monthly]

    Terminated PHASE4

    Status: Active Not Recruiting → Terminated

  2. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE4

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE4

    Status: Unknown → Active Not Recruiting

  4. Apr 2025 — Aug 2025 [monthly]

    Unknown PHASE4

    Status: Active Not Recruiting → Unknown

  5. Sep 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE4

▶ Show 13 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE4

  2. Apr 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE4

    Status: Suspended → Active Not Recruiting

  3. Mar 2022 — Apr 2023 [monthly]

    Suspended PHASE4

  4. Dec 2021 — Mar 2022 [monthly]

    Suspended PHASE4

  5. Jan 2021 — Dec 2021 [monthly]

    Suspended PHASE4

  6. Nov 2020 — Jan 2021 [monthly]

    Suspended PHASE4

  7. Jun 2020 — Nov 2020 [monthly]

    Suspended PHASE4

    Status: Recruiting → Suspended

  8. Jan 2020 — Jun 2020 [monthly]

    Recruiting PHASE4

  9. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE4

  10. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE4

  11. Feb 2019 — Oct 2019 [monthly]

    Recruiting PHASE4

  12. Oct 2018 — Feb 2019 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  13. Aug 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Albert Einstein College of Medicine
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Data source: Albert Einstein College of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations