deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT03635164

Radiotherapy With Durvalumab Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma

Phase I/Ib Trial of Radiotherapy in Combination With Durvalumab (MEDI4736) Prior to Surgical Resection for HPV Negative Squamous Cell Carcinoma of the Head and Neck (HNSCC)

Sponsor: AstraZeneca

Conditions Squamous Cell Carcinoma of the Head and Neck
Interventions Durvalumab Standard of Care Therapy Stereotactic Body Radiation Therapy (SBRT)
Updated 22 times since 2018 Last updated: Jun 23, 2025 Started: Nov 12, 2018 Primary completion: Nov 9, 2021 Completion: May 2, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Squamous Cell Carcinoma of the Head and Neck, this trial is completed. The trial is conducted by AstraZeneca and has accumulated 22 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Oct 2019 · 9 months · monthly snapshot~Oct 2019 – ~May 2020 · 7 months · monthly snapshot~May 2020 – ~Sep 2020 · 4 months · monthly snapshot~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Feb 2022 · 8 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~May 2023 · 11 months · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Apr 2024 · 9 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – present · 11 months · monthly snapshot

Change History

22 versions recorded

  1. Jul 2025 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Mar 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jan 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 17 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  4. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Jun 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  6. Feb 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  7. Jun 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  8. Feb 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  9. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  10. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  11. Sep 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  12. May 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  13. Oct 2019 — May 2020 [monthly]

    Recruiting PHASE1

  14. Jan 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  15. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  16. Nov 2018 — Dec 2018 [monthly]

    Not Yet Recruiting PHASE1

  17. Sep 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • University of Colorado, Denver
Data source: University of Colorado, Denver

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations