deltatrials
Unknown PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT03645980

DKN-01 Inhibition in Advanced Liver Cancer

A Phase I/II Multicenter, Open-label Study of DKN-01 to Investigate the Anti-tumor Activity and Safety of DKN-01 in Patients With Hepatocellular Carcinoma and WNT Signaling Alterations

Sponsor: Johannes Gutenberg University Mainz

Conditions Hepatocellular Carcinoma
Interventions DKN-01 300 mg DKN-01 600 mg Sorafenib
Updated 11 times since 2018 Last updated: Oct 20, 2020 Started: Oct 10, 2018 Primary completion: Aug 31, 2021 Completion: Aug 31, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03645980, this PHASE1/PHASE2 trial focuses on Hepatocellular Carcinoma and remains ongoing. Sponsored by Johannes Gutenberg University Mainz, it has been updated 11 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshotNot Yet Recruiting~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshotRecruiting~Jan 2019 – ~Jul 2019 · 6 months · monthly snapshotRecruiting~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshotRecruiting~Sep 2019 – ~Nov 2020 · 14 months · monthly snapshotRecruiting~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotRecruiting~Jan 2021 – ~Nov 2022 · 22 months · monthly snapshotRecruiting~Nov 2022 – ~Jul 2024 · 20 months · monthly snapshotUnknown Status~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotUnknown~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotUnknown~Sep 2025 – present · 10 months · monthly snapshotUnknown

Change History

11 versions recorded

  1. Sep 2025 — Present [monthly]

    Unknown PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Unknown PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Unknown PHASE1/PHASE2

    Status: Unknown Status → Unknown · Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Nov 2022 — Jul 2024 [monthly]

    Unknown Status PHASE1_PHASE2

    Status: Recruiting → Unknown Status

  5. Jan 2021 — Nov 2022 [monthly]

    Recruiting PHASE1_PHASE2

▶ Show 6 earlier versions

  1. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  2. Sep 2019 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  3. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE1_PHASE2

  4. Jan 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  5. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet Recruiting → Recruiting

  6. Sep 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Johannes Gutenberg University Mainz
  • Leap Therapeutics, Inc.
Data source: Johannes Gutenberg University Mainz

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations