deltatrials
Completed PHASE1 INTERVENTIONAL 3-arm NCT03649971

A Study of Guselkumab in Participants With Familial Adenomatous Polyposis

A Phase 1b, Multicenter, Randomized, Blinded, Placebo-controlled Study to Evaluate the Efficacy of Guselkumab in Subjects With Familial Adenomatous Polyposis

Sponsor: Janssen Research & Development, LLC

Conditions Adenomatous Polyposis Coli
Interventions Guselkumab Placebo
Updated 44 times since 2018 Last updated: Jan 31, 2025 Started: Nov 19, 2018 Primary completion: Sep 13, 2021 Completion: Mar 23, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Adenomatous Polyposis Coli and is currently completed. Janssen Research & Development, LLC leads this study, which shows 44 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Aug 2023 · 11 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

44 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Mar 2025 — Sep 2025 [monthly]

    Completed PHASE1

  3. Sep 2024 — Mar 2025 [monthly]

    Completed PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  5. Aug 2023 — Jul 2024 [monthly]

    Completed PHASE1

▶ Show 39 earlier versions

  1. Sep 2022 — Aug 2023 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. May 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  5. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  6. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  7. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  8. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  9. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  10. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1

  11. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  12. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1

  13. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  14. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  15. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  16. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  17. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  18. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  19. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  20. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  21. Jul 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  22. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  23. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  24. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  25. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  26. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  27. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  28. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  29. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  30. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  31. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  32. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  33. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  34. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  35. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  36. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  37. Nov 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE1

  38. Oct 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE1

  39. Sep 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Barcelona, Spain , Bonn, Germany , Boston, United States , Cleveland, United States , Columbus, United States , Duarte, United States , Houston, United States , Jacksonville, United States , Leiden, Netherlands and 19 more locations