deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 1-arm NCT03650114

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS (ALITHIOS)

An Open-label, Single Arm, Multi-center Extension Study Evaluating Long-term Safety, Tolerability and Effectiveness of Ofatumumab in Subjects With Relapsing Multiple Sclerosis

Sponsor: Novartis Pharmaceuticals

Updated 55 times since 2018 Last updated: Mar 9, 2026 Started: Dec 28, 2018 Primary completion: Dec 30, 2027 Completion: Sep 30, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03650114, this PHASE3 trial focuses on Relapsing Multiple Sclerosis and remains ongoing. Sponsored by Novartis Pharmaceuticals, it has been updated 55 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Sep 2018 – ~Feb 2019 · 5 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Apr 2020 · 5 months · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Aug 2023 · 6 months · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 59 days · monthly snapshot

Change History

55 versions recorded
  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Feb 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE3

  4. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

Show 50 earlier versions
  1. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  4. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  6. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE3

  7. Jan 2025 — Mar 2025 [monthly]

    Recruiting PHASE3

  8. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE3

    Status: Active Not RecruitingRecruiting

  9. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  10. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  11. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  12. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE3

  13. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

  14. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE3

  15. Mar 2024 — May 2024 [monthly]

    Recruiting PHASE3

  16. Nov 2023 — Mar 2024 [monthly]

    Recruiting PHASE3

  17. Aug 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  18. Feb 2023 — Aug 2023 [monthly]

    Recruiting PHASE3

  19. Nov 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  20. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  21. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  22. Apr 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  23. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  24. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  25. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  26. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  27. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  28. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  29. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  30. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  31. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  32. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE3

  33. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  34. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  35. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  36. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  37. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  38. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  39. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  40. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  41. Nov 2019 — Apr 2020 [monthly]

    Recruiting PHASE3

  42. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  43. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  44. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  45. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  46. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  47. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  48. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  49. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  50. Sep 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .