deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT03667820

Study of Osimertinib and Stereotactic Ablative Radiation (SABR) in EGFR Mutant NSCLC

Phase II Trial of Osimertinib in Combination With Stereotactic Ablative Radiation (SABR) in EGFR Mutant Advanced Non-Small Cell Lung Cancer (NSCLC)

Sponsor: AstraZeneca

Interventions Osimertinib SABR
Updated 17 times since 2018 Last updated: Oct 31, 2025 Started: Sep 26, 2018 Primary completion: Sep 30, 2027 Completion: Sep 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03667820, this PHASE2 trial focuses on Non-small Cell Lung Cancer (NSCLC) and remains ongoing. Sponsored by AstraZeneca, it has been updated 17 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~May 2019 · 4 months · monthly snapshot~May 2019 – ~May 2020 · 12 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Jun 2022 · 12 months · monthly snapshot~Jun 2022 – ~Jun 2023 · 12 months · monthly snapshot~Jun 2023 – ~May 2024 · 11 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Jun 2025 · 5 months · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Dec 2025 · 5 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

17 versions recorded
  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

Show 12 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2022 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  5. Jun 2021 — Jun 2022 [monthly]

    Recruiting PHASE2

  6. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  7. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  8. Jun 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  9. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  10. May 2019 — May 2020 [monthly]

    Recruiting PHASE2

  11. Jan 2019 — May 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  12. Oct 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Sep 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • University of Texas Southwestern Medical Center
Data source: University of Texas Southwestern Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .