deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03679624

Daratumumab Plus Ibrutinib in Patients With Waldenstrӧm's Macroglobulinemia

A Phase II Study of Daratumumab Plus Ibrutinib in Patients With Waldenstrӧm's Macroglobulinemia

Sponsor: Janssen Scientific Affairs, LLC

Conditions Waldenstrom Macroglobulinemia Waldenstrom's Disease Waldenstrom's Macroglobulinaemia, Without Mention of Remission Waldenstrom's Macroglobulinemia Recurrent Waldenstrom's Macroglobulinemia Refractory Waldenstrom's Macroglobulinemia of Lymph Nodes Waldenström; Hypergammaglobulinemia
Interventions Daratumumab Ibrutinib
Updated 18 times since 2018 Last updated: Sep 25, 2023 Started: Jul 30, 2020 Primary completion: Sep 15, 2020 Completion: Oct 13, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Low accrual

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A PHASE2 clinical study on Waldenstrom Macroglobulinemia and Waldenstrom's Disease, this trial is terminated or withdrawn. The trial is conducted by Janssen Scientific Affairs, LLC and has accumulated 18 data snapshots since 2020. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Feb 2019 · 3 months · monthly snapshot~Feb 2019 – ~May 2019 · 3 months · monthly snapshot~May 2019 – ~Oct 2019 · 5 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Jan 2022 · 12 months · monthly snapshot~Jan 2022 – ~Jan 2023 · 12 months · monthly snapshot~Jan 2023 – ~Mar 2023 · 59 days · monthly snapshot~Mar 2023 – ~Nov 2023 · 8 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

18 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  3. Nov 2023 — Jul 2024 [monthly]

    Terminated PHASE2

  4. Mar 2023 — Nov 2023 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  5. Jan 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

▶ Show 13 earlier versions

  1. Jan 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  2. Jan 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  3. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  4. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  5. May 2020 — Aug 2020 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  6. Feb 2020 — May 2020 [monthly]

    Recruiting PHASE2

  7. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE2

  8. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  9. Oct 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE2

  10. May 2019 — Oct 2019 [monthly]

    Not Yet Recruiting PHASE2

  11. Feb 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE2

  12. Nov 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE2

  13. Oct 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Scientific Affairs, LLC
  • Mayo Clinic
  • Weill Medical College of Cornell University
Data source: Weill Medical College of Cornell University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations