deltatrials
Terminated PHASE1 INTERVENTIONAL 2-arm NCT03682497

Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium

A Phase I, Open Label, Randomized, Parallel Group, Multicentre Study to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium [sK+] During 28 Days in Patients With HFmrEF or HFpEF and eGFR in the Range of ≥40 and ≤70 mL/Min/1.73m2.

Sponsor: AstraZeneca

Conditions Heart Failure
Interventions AZD9977 Spironolactone
Updated 25 times since 2018 Last updated: Apr 30, 2020 Started: Nov 1, 2018 Primary completion: Mar 31, 2020 Completion: Mar 31, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Attendance at study sites carries risk of COVID-19 infection. Non-attendance at planned study site visits has unacceptable study related patient safety risk.

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This PHASE1 trial investigates Heart Failure and is currently terminated or withdrawn. AstraZeneca leads this study, which shows 25 recorded versions since 2018 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Nov 2020 · 5 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  4. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE1

  5. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE1

▶ Show 20 earlier versions

  1. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE1

  2. Jun 2020 — Nov 2020 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  3. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  4. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  5. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  6. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  7. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  8. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  9. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  10. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  11. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  12. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  13. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  14. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  15. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE1

  16. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  17. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  18. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  19. Nov 2018 — Dec 2018 [monthly]

    Not Yet Recruiting PHASE1

  20. Oct 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Brandýs nad Labem, Czechia , Hull, United Kingdom , Jaroměř, Czechia , Katowice, Poland , Krakow, Poland , Legnica, Poland , Leicester, United Kingdom , Louny, Czechia , Pardubice, Czechia , Plovdiv, Bulgaria and 6 more locations