deltatrials
Active Not Recruiting INTERVENTIONAL NCT03684980

LTA Pilot Study of Glucarpidase in Patients With Central Nervous System Lymphoma

Sponsor: Memorial Sloan Kettering Cancer Center

Updated 28 times since 2018 Last updated: Apr 14, 2026 Started: Nov 14, 2018 Primary completion: Nov 1, 2027 Completion: Nov 1, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03684980, this observational or N/A phase trial focuses on Central Nervous System Lymphoma and remains ongoing. Sponsored by Memorial Sloan Kettering Cancer Center, it has been updated 28 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Apr 2019 · 4 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Aug 2019 · 3 months · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Mar 2020 · 3 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Aug 2023 · 8 months · monthly snapshot~Aug 2023 – ~Mar 2024 · 7 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Jun 2025 · 4 months · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Apr 2026 · 8 months · monthly snapshotApr 16, 2026 – present · 3 months · daily API

Change History

28 versions recorded
  1. Apr 16, 2026 — Present [daily]

    Active Not Recruiting

    Status: RecruitingActive Not Recruiting · Phase: EARLY_PHASE1None

  2. Aug 2025 — Apr 2026 [monthly]

    Recruiting EARLY_PHASE1

  3. Jul 2025 — Aug 2025 [monthly]

    Recruiting EARLY_PHASE1

  4. Jun 2025 — Jul 2025 [monthly]

    Recruiting EARLY_PHASE1

  5. Feb 2025 — Jun 2025 [monthly]

    Recruiting EARLY_PHASE1

Show 23 earlier versions
  1. Sep 2024 — Feb 2025 [monthly]

    Recruiting EARLY_PHASE1

  2. Aug 2024 — Sep 2024 [monthly]

    Recruiting EARLY_PHASE1

  3. Jul 2024 — Aug 2024 [monthly]

    Recruiting EARLY_PHASE1

  4. Jun 2024 — Jul 2024 [monthly]

    Recruiting EARLY_PHASE1

  5. May 2024 — Jun 2024 [monthly]

    Recruiting EARLY_PHASE1

  6. Apr 2024 — May 2024 [monthly]

    Recruiting EARLY_PHASE1

  7. Mar 2024 — Apr 2024 [monthly]

    Recruiting EARLY_PHASE1

  8. Aug 2023 — Mar 2024 [monthly]

    Recruiting EARLY_PHASE1

  9. Dec 2022 — Aug 2023 [monthly]

    Recruiting EARLY_PHASE1

  10. Sep 2022 — Dec 2022 [monthly]

    Recruiting EARLY_PHASE1

  11. Feb 2022 — Sep 2022 [monthly]

    Recruiting EARLY_PHASE1

  12. Sep 2021 — Feb 2022 [monthly]

    Recruiting EARLY_PHASE1

  13. Jan 2021 — Sep 2021 [monthly]

    Recruiting EARLY_PHASE1

  14. Jun 2020 — Jan 2021 [monthly]

    Recruiting EARLY_PHASE1

  15. May 2020 — Jun 2020 [monthly]

    Recruiting EARLY_PHASE1

  16. Mar 2020 — May 2020 [monthly]

    Recruiting EARLY_PHASE1

  17. Dec 2019 — Mar 2020 [monthly]

    Recruiting EARLY_PHASE1

  18. Nov 2019 — Dec 2019 [monthly]

    Recruiting EARLY_PHASE1

  19. Aug 2019 — Nov 2019 [monthly]

    Recruiting EARLY_PHASE1

  20. May 2019 — Aug 2019 [monthly]

    Recruiting EARLY_PHASE1

  21. Apr 2019 — May 2019 [monthly]

    Recruiting EARLY_PHASE1

  22. Dec 2018 — Apr 2019 [monthly]

    Recruiting EARLY_PHASE1

    Status: Not Yet RecruitingRecruiting

  23. Oct 2018 — Dec 2018 [monthly]

    Not Yet Recruiting EARLY_PHASE1

    First recorded

Eligibility Summary

The purpose of this study is to test the effects of a drug called Voraxaze when it's routinely given in combination with methotrexate and rituximab, the standard treatment for CNSL.

Contact Information

Sponsor contact:
  • Memorial Sloan Kettering Cancer Center
  • University of Alabama at Birmingham
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .