deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03709264

Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery. (PROTection)

Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery: a Multi-centre Randomized Blinded Placebo Controlled Clinical Trial.

Sponsor: Università Vita-Salute San Raffaele

Conditions Cardiac Surgery
Interventions Amino Acids Placebos
Updated 17 times since 2018 Last updated: Aug 5, 2025 Started: Oct 7, 2019 Primary completion: Jan 17, 2024 Completion: Jan 17, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Cardiac Surgery, this trial is completed. The trial is conducted by Università Vita-Salute San Raffaele and has accumulated 17 data snapshots since 2019. Cardiovascular trials of this type often inform treatment guidelines for long-term patient management.

Status Flow

~Nov 2018 – ~Apr 2019 · 5 months · monthly snapshot~Apr 2019 – ~Aug 2019 · 4 months · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Jul 2020 · 6 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Jan 2022 · 12 months · monthly snapshot~Jan 2022 – ~Jul 2022 · 6 months · monthly snapshot~Jul 2022 – ~Jan 2023 · 6 months · monthly snapshot~Jan 2023 – ~Feb 2024 · 13 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

17 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Feb 2025 — Sep 2025 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  3. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

▶ Show 12 earlier versions

  1. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  2. Feb 2024 — May 2024 [monthly]

    Recruiting PHASE3

  3. Jan 2023 — Feb 2024 [monthly]

    Recruiting PHASE3

  4. Jul 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  5. Jan 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  6. Jan 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  7. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  8. Jan 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  9. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  10. Aug 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE3

  11. Apr 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE3

  12. Nov 2018 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Università Vita-Salute San Raffaele
Data source: Università Vita-Salute San Raffaele

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Castel Volturno, Italy , Catanzaro, Italy , Cotignola, Italy , Dubrava, Croatia , Genoa, Italy , Massa, Italy , Miano, Italy , Milan, Italy , Napoli, Italy , Palermo, Italy and 9 more locations