deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03712904

Stereotactic Body Radiation Therapy and Aflibercept in Treating Patients With Uveal Melanoma

Phase II Randomized Trial of Stereotactic Radiotherapy (SRT) Followed by Intravitreal Aflibercept Injection for Patients With Ocular Melanoma

Sponsor: Regeneron Pharmaceuticals

Conditions Uveal Melanoma
Updated 14 times since 2018 Last updated: Sep 4, 2025 Started: Aug 9, 2019 Primary completion: Sep 20, 2022 Completion: Dec 23, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Slow accrual

Listed as NCT03712904, this PHASE2 trial focuses on Uveal Melanoma and remains terminated or withdrawn. Sponsored by Regeneron Pharmaceuticals, it has been updated 14 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Nov 2018 – ~Feb 2019 · 3 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Jan 2021 · 16 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2025 · 13 months · monthly snapshot~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

14 versions recorded
  1. Feb 2026 — Present [monthly]

    Terminated PHASE2

  2. Oct 2025 — Feb 2026 [monthly]

    Terminated PHASE2

    Status: CompletedTerminated

  3. Sep 2024 — Oct 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Feb 2023 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

Show 9 earlier versions
  1. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  2. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  3. Sep 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  5. Sep 2019 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  6. Jun 2019 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE2

  7. Apr 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE2

  8. Feb 2019 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE2

  9. Nov 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Regeneron Pharmaceuticals
  • Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Data source: Thomas Jefferson University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations