deltatrials
Completed PHASE2/PHASE3 INTERVENTIONAL 7-arm NCT03732807

PF-06651600 for the Treatment of Alopecia Areata (ALLEGRO-2b/3)

A PHASE 2B/3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF PF-06651600 IN ADULT AND ADOLESCENT ALOPECIA AREATA (AA) SUBJECTS WITH 50% OR GREATER SCALP HAIR LOSS

Sponsor: Pfizer

Conditions Alopecia Areata
Interventions PF-06651600 Induction Dose PF-06651600 Maintenance Dose #1 PF-06651600 Maintenance Dose #2 PF-06651600 Maintenance Dose #3 Placebo
Updated 36 times since 2018 Last updated: Feb 1, 2022 Started: Dec 3, 2018 Primary completion: Dec 31, 2020 Completion: Jun 24, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2/PHASE3 trial investigates Alopecia Areata and is currently completed. Pfizer leads this study, which shows 36 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Mar 2022 · 4 months · monthly snapshot~Mar 2022 – ~Jul 2024 · 28 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

36 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2/PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2/PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2/PHASE3

    Phase: PHASE2_PHASE3 → PHASE2/PHASE3

  4. Mar 2022 — Jul 2024 [monthly]

    Completed PHASE2_PHASE3

    Phase: PHASE3 → PHASE2_PHASE3

  5. Nov 2021 — Mar 2022 [monthly]

    Completed PHASE3

▶ Show 31 earlier versions

  1. Oct 2021 — Nov 2021 [monthly]

    Completed PHASE3

  2. Sep 2021 — Oct 2021 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed · Phase: PHASE2_PHASE3 → PHASE3

  3. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Phase: PHASE3 → PHASE2_PHASE3

  4. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

    Phase: PHASE2_PHASE3 → PHASE3

  5. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  6. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  7. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  8. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  9. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  10. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: Recruiting → Active Not Recruiting

  11. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2_PHASE3

  12. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2_PHASE3

  13. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2_PHASE3

  14. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE2_PHASE3

  15. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2_PHASE3

  16. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2_PHASE3

  17. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2_PHASE3

  18. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2_PHASE3

  19. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2_PHASE3

  20. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2_PHASE3

  21. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2_PHASE3

  22. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2_PHASE3

  23. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2_PHASE3

  24. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2_PHASE3

  25. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2_PHASE3

  26. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2_PHASE3

  27. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2_PHASE3

  28. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2_PHASE3

  29. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2_PHASE3

  30. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Not Yet Recruiting → Recruiting

  31. Dec 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Pfizer
Data source: Pfizer

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Bad Bentheim, Germany , Badalona, Spain , Barcelona, Spain , Beijing, China , Benowa, Australia , Berlin, Germany , Beverly Hills, United States , Birmingham, United States , Bogotá, Colombia and 97 more locations