deltatrials
Suspended PHASE1 INTERVENTIONAL 2-arm NCT03737448

TRimetazidine for acUte on Chronic Liver Failure STudy (TRUST)

A Phase 1b Open-Label Study Assessing the Pharmacokinetics, Tolerability, and Safety of Oral Trimetazidine in Subjects With Acute-on-Chronic Liver Failure

Sponsor: Martin Pharmaceuticals

Interventions Trimetazidine
Updated 14 times since 2018 Last updated: Mar 2, 2021 Started: Nov 28, 2018 Primary completion: Jun 30, 2021 Completion: Jun 30, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Suspended

Lack of enrollment

This PHASE1 trial investigates Acute-On-Chronic Liver Failure and is currently suspended. Martin Pharmaceuticals leads this study, which shows 14 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Nov 2019 · 5 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jul 2024 · 39 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

14 versions recorded
  1. Sep 2025 — Present [monthly]

    Suspended PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Suspended PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Suspended PHASE1

  4. Apr 2021 — Jul 2024 [monthly]

    Suspended PHASE1

    Status: RecruitingSuspended

  5. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

Show 9 earlier versions
  1. Feb 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  2. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  3. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  4. Jun 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  5. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  6. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  7. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  8. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  9. Dec 2018 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Nov 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Martin Pharmaceuticals
Data source: Martin Pharmaceuticals

For direct contact, visit the study record on ClinicalTrials.gov .