Completed NA INTERVENTIONAL 1-arm NCT03739905

ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease

A Phase IIa Study to Evaluate the Safety and Efficacy of Blood-Brain Barrier (BBB) Opening Using Transcranial MR-Guided Focused Ultrasound in Patients With Alzheimer's Disease

Sponsor: Focused Ultrasound Foundation

Conditions Alzheimer Disease

Interventions Blood Brain Barrier (BBB) Disruption

Updated 12 times since 2018 Last updated: Jan 16, 2026 Started: Dec 6, 2018 Primary completion: Apr 9, 2025 Completion: Apr 9, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Alzheimer Disease and is currently completed. Focused Ultrasound Foundation leads this study, which shows 12 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

12 versions recorded

Feb 2026 — Present [monthly]

Completed NA

Status: Unknown → Completed
Mar 2025 — Feb 2026 [monthly]

Unknown NA

Status: Recruiting → Unknown
Sep 2024 — Mar 2025 [monthly]

Recruiting NA
Jul 2024 — Sep 2024 [monthly]

Recruiting NA
Apr 2023 — Jul 2024 [monthly]

Recruiting NA

▶ Show 7 earlier versions

Nov 2021 — Apr 2023 [monthly]

Recruiting NA
Jan 2021 — Nov 2021 [monthly]

Recruiting NA
Oct 2020 — Jan 2021 [monthly]

Recruiting NA
Feb 2020 — Oct 2020 [monthly]

Recruiting NA
Apr 2019 — Feb 2020 [monthly]

Recruiting NA
Mar 2019 — Apr 2019 [monthly]

Recruiting NA

Status: Not Yet Recruiting → Recruiting
Dec 2018 — Mar 2019 [monthly]

Not Yet Recruiting NA

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Focused Ultrasound Foundation
InSightec

Data source: InSightec

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Toronto, Canada