deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 11-arm NCT03740529

A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHL

A Phase 1/2 Study of Oral LOXO-305 in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) or Non-Hodgkin Lymphoma (NHL)

Sponsor: Eli Lilly and Company

Updated 25 times since 2018 Last updated: Jan 26, 2026 Started: Mar 15, 2019 Primary completion: Jan 27, 2025 Completion: Dec 23, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates B-cell Lymphoma and Chronic Lymphocytic Leukemia and is currently completed. Eli Lilly and Company leads this study, which shows 25 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Jun 2019 · 4 months · monthly snapshot~Jun 2019 – ~Nov 2019 · 5 months · monthly snapshot~Nov 2019 – ~Apr 2020 · 5 months · monthly snapshot~Apr 2020 – ~Nov 2020 · 7 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Feb 2022 · 4 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Apr 2024 · 12 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~May 2025 · 6 months · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 4 months · monthly snapshot

Change History

25 versions recorded
  1. Feb 2026 — Present [monthly]

    Completed PHASE1/PHASE2

    Status: Active Not RecruitingCompleted

  2. Oct 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Jul 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  5. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

Show 20 earlier versions
  1. Nov 2024 — May 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Apr 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: RecruitingActive Not Recruiting

  7. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1_PHASE2

  8. Sep 2022 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

  9. Feb 2022 — Sep 2022 [monthly]

    Recruiting PHASE1_PHASE2

  10. Oct 2021 — Feb 2022 [monthly]

    Recruiting PHASE1_PHASE2

  11. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

  12. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE1_PHASE2

  14. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  15. Apr 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  16. Nov 2019 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jun 2019 — Nov 2019 [monthly]

    Recruiting PHASE1_PHASE2

  18. Feb 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet RecruitingRecruiting

  20. Dec 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
  • Loxo Oncology, Inc.
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .