deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT03742414

Seal, Stopping Eczema and Allergy Study

SEAL (Stopping Eczema and ALlergy) Study: Prevent the Allergic March by Enhancing the Skin Barrier

Sponsor: Children's Hospital Medical Center, Cincinnati

Conditions Atopic Dermatitis Atopic Dermatitis Eczema Eczema Eczema, Infantile
Interventions Fluticasone propionate Cream 0.05% Standard of Care Tri-lipid skin barrier cream (Epiceram)
Updated 23 times since 2018 Last updated: Feb 25, 2026 Started: Jun 30, 2021 Primary completion: May 31, 2028 Completion: Jun 30, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Atopic Dermatitis and Atopic Dermatitis Eczema, this trial is ongoing. The trial is conducted by Children's Hospital Medical Center, Cincinnati and has accumulated 23 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Dec 2018 – ~Oct 2019 · 10 months · monthly snapshot~Oct 2019 – ~Aug 2020 · 10 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Jun 2022 · 6 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Jun 2024 · 7 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Feb 2026 · 7 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

23 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. May 2025 — Jul 2025 [monthly]

    Recruiting PHASE2

  4. Mar 2025 — May 2025 [monthly]

    Recruiting PHASE2

  5. Sep 2024 — Mar 2025 [monthly]

    Recruiting PHASE2

▶ Show 18 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  2. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Nov 2023 — Jun 2024 [monthly]

    Recruiting PHASE2

  4. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  5. Jul 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  6. May 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  7. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  8. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  9. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  10. Jul 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  11. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  12. Dec 2021 — Jun 2022 [monthly]

    Recruiting PHASE2

  13. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  14. Jun 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE2

    Phase: PHASE1_PHASE2 → PHASE2

  15. Jan 2021 — Jun 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  16. Aug 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  17. Oct 2019 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  18. Dec 2018 — Oct 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Hospital Medical Center, Cincinnati
  • Guy's and St Thomas' NHS Foundation Trust
  • Harvard School of Public Health (HSPH)
  • Kari Nadeau, MD, PhD
  • King's College London
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Jewish Health
  • Stanford University
  • University of Chicago
Data source: Harvard School of Public Health (HSPH)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations