deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT03745898

The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea

The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea (LOFT-HF)

Sponsor: Brigham and Women's Hospital

Interventions Oxygen Room Air
Updated 15 times since 2018 Last updated: Jul 10, 2023 Started: Apr 15, 2019 Primary completion: Jun 17, 2022 Completion: Jun 17, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Low feasibility of completion within the study period due to delayed site activation and slow participant accrual

Listed as NCT03745898, this PHASE3 trial focuses on Central Sleep Apnea and Heart Failure and remains terminated or withdrawn. Sponsored by Brigham and Women's Hospital, it has been updated 15 times since 2019, reflecting substantial change activity. This study contributes longitudinal data to the cardiovascular research landscape.

Status Flow

~Dec 2018 – ~Sep 2019 · 9 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Feb 2020 · 4 months · monthly snapshot~Feb 2020 – ~Jun 2020 · 4 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Jun 2022 · 9 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

15 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  4. Sep 2023 — Jul 2024 [monthly]

    Terminated PHASE3

  5. Sep 2022 — Sep 2023 [monthly]

    Terminated PHASE3

    Status: Active Not RecruitingTerminated

Show 10 earlier versions
  1. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  3. Mar 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  4. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  5. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  6. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  7. Feb 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  8. Oct 2019 — Feb 2020 [monthly]

    Recruiting PHASE3

  9. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  10. Dec 2018 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Brigham and Women's Hospital
  • Ohio State University
Data source: Brigham and Women's Hospital

For direct contact, visit the study record on ClinicalTrials.gov .