deltatrials
Unknown PHASE2 INTERVENTIONAL 2-arm NCT03748680

IMPROVE Intervention Trial Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer (IMPROVE-IT)

Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer

Sponsor: Karen-Lise Garm Spindler

Conditions Adjuvant Chemotherapy Circulating Tumor DNA Colorectal Cancer Progression Free Survival
Interventions Capox (or FOLFOX) including flouropyrimidine and oxaliplatin combination chemotherapy Intensified Follow-up Schedule
Updated 7 times since 2018 Last updated: Feb 24, 2022 Started: Oct 1, 2018 Primary completion: Oct 1, 2023 Completion: Oct 1, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Adjuvant Chemotherapy and Circulating Tumor DNA and is currently ongoing. Karen-Lise Garm Spindler leads this study, which shows 7 recorded versions since 2018 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshotRecruiting~Jan 2019 – ~Jan 2021 · 24 months · monthly snapshotRecruiting~Jan 2021 – ~Mar 2022 · 14 months · monthly snapshotRecruiting~Mar 2022 – ~Jul 2024 · 28 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Nov 2025 · 14 months · monthly snapshotRecruiting~Nov 2025 – present · 9 months · monthly snapshotUnknown

Change History

7 versions recorded

  1. Nov 2025 — Present [monthly]

    Unknown PHASE2

    Status: Recruiting → Unknown

  2. Sep 2024 — Nov 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. Mar 2022 — Jul 2024 [monthly]

    Recruiting PHASE2

  5. Jan 2021 — Mar 2022 [monthly]

    Recruiting PHASE2

▶ Show 2 earlier versions

  1. Jan 2019 — Jan 2021 [monthly]

    Recruiting PHASE2

  2. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

    First recorded

Oct 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Karen-Lise Garm Spindler
Data source: Aarhus University Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations