deltatrials
Completed PHASE3 INTERVENTIONAL 4-arm NCT03777059

12-Week Placebo-controlled Study of Atogepant for the Preventive Treatment of Migraine in Participants With Episodic Migraine

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy, Safety, and Tolerability of Oral Atogepant for the Prevention of Migraine in Participants With Episodic Migraine (ADVANCE)

Sponsor: Allergan

Conditions Episodic Migraine
Interventions Atogepant Placebo
Updated 21 times since 2019 Last updated: Jun 18, 2021 Started: Dec 14, 2018 Primary completion: Jun 19, 2020 Completion: Jun 19, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03777059, this PHASE3 trial focuses on Episodic Migraine and remains completed. Sponsored by Allergan, it has been updated 21 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Jul 2024 · 34 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

21 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Sep 2021 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE3

▶ Show 16 earlier versions

  1. Aug 2020 — Jan 2021 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  3. Apr 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  4. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  5. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  6. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  7. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  8. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  9. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  10. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  11. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  12. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  13. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  14. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  15. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  16. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

    First recorded

Dec 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Allergan
Data source: Allergan

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albuquerque, United States , Ames, United States , Amherst, United States , Anderson, United States , Atlanta, United States , Austin, United States , Aventura, United States , Baltimore, United States , Bay Saint Louis, United States and 105 more locations