Completed PHASE3 INTERVENTIONAL 2-arm NCT03785340

Study of Brimonidine Tartrate Nanoemulsion Eye Drop Solution in the Treatment of Dry Eye Disease (DED)

A Phase 3 Randomized, Placebo-Controlled, Double-Masked, Multicenter, Safety and Efficacy Study of Brimonidine Tartrate 0.2% Nanoemulsion Eye Drops in Patients With Dry Eye Disease (DED)

Sponsor: Ocugen

Conditions Dry Eye

Interventions Brimonidine Tartrate Placebos

Updated 9 times since 2019 Last updated: Jun 29, 2022 Started: Dec 3, 2018 Primary completion: Feb 25, 2019 Completion: Feb 25, 2019

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Dry Eye and is currently completed. Ocugen leads this study, which shows 9 recorded versions since 2018 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Sep 2022 — Jul 2024 [monthly]

Completed PHASE3
Jul 2022 — Sep 2022 [monthly]

Completed PHASE3

▶ Show 4 earlier versions

Jan 2021 — Jul 2022 [monthly]

Completed PHASE3
Aug 2020 — Jan 2021 [monthly]

Completed PHASE3

Status: Recruiting → Completed
Feb 2019 — Aug 2020 [monthly]

Recruiting PHASE3
Jan 2019 — Feb 2019 [monthly]

Recruiting PHASE3

First recorded

Dec 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Ocugen

Data source: Ocugen

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Cincinnati, United States , Cleveland, United States , Cranberry Township, United States , Hoffman Estates, United States , Houston, United States , Lakeway, United States , Memphis, United States , Mission, United States , Nashville, United States , Newport Beach, United States and 4 more locations