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Completed PHASE2 INTERVENTIONAL 2-arm NCT03797326

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

A Multicenter, Open-label Phase 2 Study of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) in Previously Treated Subjects With Selected Solid Tumors (LEAP-005)

Sponsor: Eisai Inc.

Updated 41 times since 2019 Last updated: Oct 31, 2025 Started: Feb 12, 2019 Primary completion: Oct 28, 2024 Completion: Oct 28, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Advanced Solid Tumors and Biliary Tract Cancers, this trial is completed. The trial is conducted by Eisai Inc. and has accumulated 41 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Aug 2020 · 5 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jun 2022 · 6 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2023 · 14 months · monthly snapshot~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshot

Change History

41 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE2

  2. Nov 2025 — Dec 2025 [monthly]

    Completed PHASE2

  3. Sep 2025 — Nov 2025 [monthly]

    Completed PHASE2

  4. Dec 2024 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  5. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

Show 36 earlier versions
  1. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Nov 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Sep 2022 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  7. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  8. Dec 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  9. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  10. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  11. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  12. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  13. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  14. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  15. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  16. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  17. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  18. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  19. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  20. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  21. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  22. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

    Status: Active Not RecruitingRecruiting

  23. Mar 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  24. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  25. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  26. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  27. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  28. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  29. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  30. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  31. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  32. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  33. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  34. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  35. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  36. Feb 2019 — Mar 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eisai Inc.
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .