deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03833167

Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)

A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate Pembrolizumab Versus Placebo as Adjuvant Therapy Following Surgery and Radiation in Participants With High-risk Locally Advanced Cutaneous Squamous Cell Carcinoma (LA cSCC) (KEYNOTE-630)

Sponsor: Merck Sharp & Dohme LLC

Conditions Carcinoma, Squamous Cell
Interventions Pembrolizumab Placebo
Updated 67 times since 2019 Last updated: Feb 17, 2026 Started: Apr 1, 2019 Primary completion: Jun 28, 2024 Completion: Jan 20, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Carcinoma, Squamous Cell, this trial is completed. The trial is conducted by Merck Sharp & Dohme LLC and has accumulated 67 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Jul 2025 · 7 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 2 months · monthly snapshot

Change History

67 versions recorded

  1. Mar 2026 — Present [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Jan 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 62 earlier versions

  1. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Dec 2024 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Oct 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  6. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  7. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE3

  8. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE3

  9. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE3

  10. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE3

  11. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE3

  12. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  13. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  14. Aug 2023 — Oct 2023 [monthly]

    Recruiting PHASE3

  15. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE3

  16. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  17. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  18. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE3

  19. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  20. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  21. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE3

  22. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  23. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  24. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  25. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  26. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  27. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  28. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  29. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  30. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  31. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  32. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  33. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  34. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  35. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  36. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  37. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  38. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  39. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  40. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  41. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  42. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  43. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  44. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  45. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  46. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  47. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  48. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  49. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  50. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  51. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  52. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  53. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE3

  54. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  55. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  56. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  57. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  58. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  59. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  60. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  61. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  62. Mar 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Antofagasta, Chile , Athens, Greece , Atlanta, United States , Auckland, New Zealand , Aurora, United States , Barcelona, Spain , Bari, Italy , Beersheba, Israel , Bento Gonçalves, Brazil , Bergen, Norway and 145 more locations