deltatrials
Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT03842696

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

A Phase 1/2 Multi-Center Trial of Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

Sponsor: National Center for Advancing Translational Sciences (NCATS)

Conditions Acute Leukemia in Remission Chronic Myelogenous Leukemia - Chronic Phase Chronic Myelogenous Leukemia, Accelerated Phase Chronic Myelogenous Leukemia, Blastic Phase Diffuse Large B Cell Lymphoma Follicular Lymphoma Graft Vs Host Disease Graft-versus-host-disease Hematologic Diseases Mantle Cell Lymphoma Myelodysplastic Syndromes Non Hodgkin Lymphoma
Interventions Blood and Marrow Transplant (BMT) Cyclophosphamide Methotrexate Mycophenolate Mofetil (MMF) Tacrolimus (or cyclosporine) Vorinostat
Updated 22 times since 2019 Last updated: Jan 23, 2026 Started: Feb 4, 2020 Primary completion: Jul 30, 2025 Completion: Apr 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03842696, this PHASE1/PHASE2 trial focuses on Acute Leukemia in Remission and Chronic Myelogenous Leukemia - Chronic Phase and remains ongoing. Sponsored by National Center for Advancing Translational Sciences (NCATS), it has been updated 22 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Oct 2021 · 8 months · monthly snapshot~Oct 2021 – ~Jan 2022 · 3 months · monthly snapshot~Jan 2022 – ~Jan 2023 · 12 months · monthly snapshot~Jan 2023 – ~May 2023 · 4 months · monthly snapshot~May 2023 – ~Dec 2023 · 7 months · monthly snapshot~Dec 2023 – ~Apr 2024 · 4 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Feb 2026 · 9 months · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

22 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. May 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Sep 2024 — May 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  5. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE1_PHASE2

▶ Show 17 earlier versions

  1. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1_PHASE2

  2. Dec 2023 — Apr 2024 [monthly]

    Recruiting PHASE1_PHASE2

  3. May 2023 — Dec 2023 [monthly]

    Recruiting PHASE1_PHASE2

  4. Jan 2023 — May 2023 [monthly]

    Recruiting PHASE1_PHASE2

  5. Jan 2022 — Jan 2023 [monthly]

    Recruiting PHASE1_PHASE2

  6. Oct 2021 — Jan 2022 [monthly]

    Recruiting PHASE1_PHASE2

  7. Feb 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

  8. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  9. Jun 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  10. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  11. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  12. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  13. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE1_PHASE2

  14. Jul 2019 — Oct 2019 [monthly]

    Recruiting PHASE1_PHASE2

  15. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet Recruiting → Recruiting

  16. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  17. Mar 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Center for Advancing Translational Sciences (NCATS)
  • National Institutes of Health (NIH)
  • University of Michigan Rogel Cancer Center
Data source: University of Michigan Rogel Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations