deltatrials
Terminated PHASE2/PHASE3 INTERVENTIONAL 4-arm NCT03870750

Identifying Best Approach in Improving Quality of Life and Survival After a Donor Stem Cell Transplant in Older, Medically Infirm, or Frail Patients With Blood Diseases

Seamless Phase II-Phase III Randomized Clinical Trial to Identify and Confirm the Most Promising Novel Intervention to Alleviate Morbidity and Mortality After Allogeneic Hematopoietic Cell Transplantation Among Older, Medically Infirm, or Frail Patients With Hematological Diseases

Sponsor: Fred Hutchinson Cancer Center

Updated 30 times since 2019 Last updated: Jan 8, 2026 Started: Aug 15, 2019 Primary completion: Dec 31, 2025 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study terminated due to meeting interim analysis futility endpoint. No difference was found between two treatment arms at interim analysis of primary outcome.

This PHASE2/PHASE3 trial investigates Hematopoietic and Lymphoid Cell Neoplasm and Non-Neoplastic Hematologic and Lymphocytic Disorder and is currently terminated or withdrawn. Fred Hutchinson Cancer Center leads this study, which shows 30 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Apr 2019 – ~Aug 2019 · 4 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~May 2020 · 4 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~May 2022 · 5 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Jun 2023 · 3 months · monthly snapshot~Jun 2023 – ~Feb 2024 · 8 months · monthly snapshot~Feb 2024 – ~Jun 2024 · 4 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Jul 2025 · 5 months · monthly snapshot~Jul 2025 – ~Feb 2026 · 7 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

30 versions recorded
  1. Feb 2026 — Present [monthly]

    Terminated PHASE2/PHASE3

    Status: Active Not RecruitingTerminated

  2. Jul 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2/PHASE3

  3. Feb 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2/PHASE3

    Status: RecruitingActive Not Recruiting

  4. Sep 2024 — Feb 2025 [monthly]

    Recruiting PHASE2/PHASE3

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2/PHASE3

Show 25 earlier versions
  1. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2/PHASE3

    Phase: PHASE2_PHASE3PHASE2/PHASE3

  2. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2_PHASE3

  3. Feb 2024 — Jun 2024 [monthly]

    Recruiting PHASE2_PHASE3

  4. Jun 2023 — Feb 2024 [monthly]

    Recruiting PHASE2_PHASE3

  5. Mar 2023 — Jun 2023 [monthly]

    Recruiting PHASE2_PHASE3

  6. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2_PHASE3

  7. Sep 2022 — Feb 2023 [monthly]

    Recruiting PHASE2_PHASE3

  8. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2_PHASE3

  9. May 2022 — Jul 2022 [monthly]

    Recruiting PHASE2_PHASE3

  10. Dec 2021 — May 2022 [monthly]

    Recruiting PHASE2_PHASE3

  11. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2_PHASE3

  12. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2_PHASE3

  13. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2_PHASE3

  14. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2_PHASE3

  15. Mar 2021 — Jun 2021 [monthly]

    Recruiting PHASE2_PHASE3

  16. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2_PHASE3

  17. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2_PHASE3

  18. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2_PHASE3

  19. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2_PHASE3

  20. May 2020 — Aug 2020 [monthly]

    Recruiting PHASE2_PHASE3

  21. Jan 2020 — May 2020 [monthly]

    Recruiting PHASE2_PHASE3

  22. Oct 2019 — Jan 2020 [monthly]

    Recruiting PHASE2_PHASE3

  23. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Not Yet RecruitingRecruiting

  24. Aug 2019 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

  25. Apr 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Fred Hutchinson Cancer Center
  • National Cancer Institute (NCI)
  • National Institutes of Health (NIH)
Data source: Fred Hutchinson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .