Completed NA INTERVENTIONAL 2-arm NCT03891342

Effect of Fluid Challenge on Glycocalyx

Comparing of Two Regimes (Fast and Slow) of Fluid Challenge on Glycocalyx Assessed by Perfused Boundary Region in Septic and Elective Major Surgical Patients

Sponsor: University Hospital Hradec Kralove

Conditions Anesthesia Endothelial Dysfunction Sepsis Septic Shock Surgery

Interventions Fluid bolus administration

Updated 5 times since 2019 Last updated: Mar 25, 2019 Started: Feb 29, 2016 Primary completion: Jul 31, 2018 Completion: Aug 31, 2018

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Anesthesia and Endothelial Dysfunction and is currently completed. University Hospital Hradec Kralove leads this study, which shows 5 recorded versions since 2016 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

5 versions recorded

Sep 2025 — Present [monthly]

Completed NA
Sep 2024 — Sep 2025 [monthly]

Completed NA
Jul 2024 — Sep 2024 [monthly]

Completed NA
Jan 2021 — Jul 2024 [monthly]

Completed NA
Apr 2019 — Jan 2021 [monthly]

Completed NA

First recorded

Feb 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

University Hospital Hradec Kralove
University Hospital Pilsen

Data source: University Hospital Hradec Kralove

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Pilsen, Czechia