deltatrials
Completed PHASE2 INTERVENTIONAL 8-arm NCT03891524

A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery (AXIOMATIC-TKR)

A Randomized, Open-Label, Study Drug-Dose Blind, Multicenter Study to Evaluate the Efficacy and Safety of JNJ-70033093 (BMS-986177), an Oral Factor XIa Inhibitor, Versus Subcutaneous Enoxaparin in Subjects Undergoing Elective Total Knee Replacement Surgery

Sponsor: Bristol-Myers Squibb

Conditions Arthroplasty, Replacement, Knee
Interventions Enoxaparin 40 mg JNJ-70033093 100 mg JNJ-70033093 200 mg JNJ-70033093 25 mg JNJ-70033093 50 mg Placebo
Updated 30 times since 2019 Last updated: Mar 28, 2025 Started: Jun 17, 2019 Primary completion: Apr 6, 2021 Completion: Apr 6, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03891524, this PHASE2 trial focuses on Arthroplasty, Replacement, Knee and remains completed. Sponsored by Bristol-Myers Squibb, it has been updated 30 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2022 · 15 months · monthly snapshot~Sep 2022 – ~Jul 2024 · 22 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

30 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Apr 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Apr 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Sep 2022 — Jul 2024 [monthly]

    Completed PHASE2

▶ Show 25 earlier versions

  1. Jun 2021 — Sep 2022 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  2. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

  3. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  5. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  6. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  7. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  8. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  9. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  10. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  11. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  12. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  13. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  14. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  15. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  16. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  17. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  18. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  19. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  20. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  21. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  22. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  23. Jun 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE2

  24. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE2

  25. Apr 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adana, Turkey (Türkiye) , Ajax, Canada , Alcorcón, Spain , Ankara, Turkey (Türkiye) , Antalya, Turkey (Türkiye) , Antwerp, Belgium , Aveiro, Portugal , Badalona, Spain , Barcelona, Spain , Belo Horizonte, Brazil and 95 more locations